Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.47 |
| ▸ | ADH1C | P00326 | 1/20 | 0.47 |
| ▸ | ADH1A | P07327 | 1/20 | 0.47 |
| ▸ | ADH7 | P40394 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515077 | 0.81 | ADH1B (0.47) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL30595834 | 0.80 | ADH1B (0.62) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL8763191 | 0.80 | ADH1B (0.62) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL5542317 | 0.75 | ADH1B (0.52) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL514207 | 0.75 | NPC1 (0.55) | ADH1BADH1CADH1AADH7KDM4E | |
| SCHEMBL23599602 | 0.75 | CYP1A1 (0.30) | — | |
| SCHEMBL8763256 | 0.74 | ADH1B (0.56) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL8379179 | 0.72 | ADH1B (0.54) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL5546697 | 0.72 | ADH1B (0.54) | ADH1BADH1CADH1AADH7TSHR | |
| SCHEMBL4953056 | 0.71 | GABRA1 (0.46) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183523-A1 | HETERO-BIFUNCTIONAL DEGRADER COMPOUNDS AND THEIR USE AS MODULATORS OF TARGETED UBIQUINATION (VHL) | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |