⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24816239 | 0.70 | — | — | |
| SCHEMBL28103152 | 0.69 | — | — | |
| SCHEMBL3215267 | 0.69 | — | — | |
| SCHEMBL28279048 | 0.69 | — | — | |
| SCHEMBL22520015 | 0.65 | POLB (0.31) | — | |
| SCHEMBL22519854 | 0.65 | HTR2A (0.30) | — | |
| SCHEMBL24500941 | 0.64 | — | — | |
| SCHEMBL721683 | 0.63 | — | — | |
| SCHEMBL27550673 | 0.63 | NOS2 (0.30) | — | |
| SCHEMBL27545251 | 0.63 | NOS2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689367-B2 | Triazole pyridyl compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190300507-A1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2019-10-03 | — | — | US | disclosed |