Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408164 | 0.80 | HSD17B10 (0.33) | SMN1; SMN2USP2CTSKHSD17B10NR1H2 | |
| SCHEMBL24845877 | 0.77 | HSD17B10 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL27172955 | 0.77 | HSD17B10 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL21408122 | 0.76 | USP2 (0.39) | SMN1; SMN2USP2HSD17B10NR1H2 | |
| SCHEMBL1643826 | 0.76 | USP2 (0.39) | SMN1; SMN2USP2HSD17B10NR1H2 | |
| SCHEMBL16224365 | 0.75 | USP2 (0.38) | SMN1; SMN2USP2CTSKHSD17B10NR1H2 | |
| SCHEMBL21408125 | 0.74 | ACACB (0.40) | SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL17631948 | 0.73 | HSD17B10 (0.38) | SMN1; SMN2USP2HSD17B10NR1H2 | |
| SCHEMBL13449262 | 0.72 | JAK2 (0.37) | ALDH1A1SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL21408146 | 0.72 | ACACB (0.41) | SMN1; SMN2USP2HSD17B10KDM1ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573500-B | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-110573500-A | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |