Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408125 | 0.84 | ACACB (0.40) | ACACBUSP2SMN1; SMN2HSD17B10 | |
| SCHEMBL21408122 | 0.78 | USP2 (0.39) | NR1H2RXRANR1H3USP2SMN1; SMN2 | |
| SCHEMBL1643826 | 0.78 | USP2 (0.39) | NR1H2RXRANR1H3USP2SMN1; SMN2 | |
| SCHEMBL16224365 | 0.76 | USP2 (0.38) | ACACBNR1H2RXRANR1H3USP2 | |
| SCHEMBL29519395 | 0.76 | USP30 (0.33) | ACACBNR1H2RXRANR1H3USP2 | |
| SCHEMBL29519100 | 0.75 | RORC (0.34) | ACACBNR1H2RXRANR1H3GPR119 | |
| SCHEMBL25232248 | 0.74 | CHRM2 (0.40) | ACACBNR1H2RXRANR1H3USP2 | |
| SCHEMBL17631948 | 0.74 | HSD17B10 (0.38) | NR1H2RXRANR1H3USP2SMN1; SMN2 | |
| SCHEMBL24845890 | 0.74 | SMN1; SMN2 (0.40) | ACACBUSP2SMN1; SMN2HSD17B10 | |
| SCHEMBL22720242 | 0.74 | USP2 (0.43) | USP2SMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |