Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.68 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.68 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228881 | 0.99 | KCNH2 (0.81) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL223800 | 0.99 | KCNH2 (0.81) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| Hydrochloric Acid SCHEMBL8404070 | 0.97 | KCNH2 (0.80) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL4224568 | 0.92 | HRH3 (0.93) | HRH3KCNH2KDM4EKMT2AALDH1A1 | |
| SCHEMBL4096430 | 0.89 | HRH3 (1.00) | HRH3KCNH2KDM4EALDH1A1LMNA | |
| SCHEMBL4441360 | 0.88 | SMN1; SMN2 (0.73) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL9199244 | 0.88 | KCNH2 (0.63) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL17758913 | 0.86 | HRH3 (0.72) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL4441264 | 0.86 | HRH3 (0.61) | HRH3KCNH2KDM4EPSMB1PSMB5 | |
| SCHEMBL2229668 | 0.86 | KDM4E (0.90) | HRH3KCNH2KDM4EPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047297-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-02-18 | — | — | US | disclosed |
| US-20210047297-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-02-18 | — | — | US | disclosed |
| EP-3774769-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | Bayer Pharma Aktiengesellschaft (DE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019185525-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-03 | — | — | WO | disclosed |
| WO-2019185525-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047297-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | PKD1, CDKN1A, VHL | HRH3 144/4885KCNH2 1193/4885KDM4E 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.