Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | THRB | P10828 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.70 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | HRH2 | P25021 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | HRH1 | P35367 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223800 | 0.88 | KCNH2 (0.81) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| SCHEMBL228881 | 0.88 | KCNH2 (0.81) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL8404070 | 0.87 | KCNH2 (0.80) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| SCHEMBL4224568 | 0.87 | HRH3 (0.93) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| SCHEMBL21408538 | 0.86 | HRH3 (0.79) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| SCHEMBL17754529 | 0.86 | KMT2A (0.65) | HRH3KMT2AKCNH2THRBALDH1A1 | |
| SCHEMBL501910 | 0.85 | KMT2A (0.72) | HRH3KMT2AKCNH2ALDH1A1LMNA | |
| SCHEMBL4096430 | 0.84 | HRH3 (1.00) | HRH3KCNH2THRBALDH1A1LMNA | |
| SCHEMBL502023 | 0.83 | KMT2A (0.69) | HRH3KMT2AKCNH2ALDH1A1LMNA | |
| Dyclonine SCHEMBL25773 | 0.83 | THRB (1.00) | HRH3KMT2AKCNH2THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662318-B2 | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof | BARRY UNIVERSITY, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160136145-A1 | BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF | BARRY UNIVERSITY, INC. | 2016-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160136145-A1 | BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF | CHRM5, CHRM2, CHRM3 | HRH3 104/4885KMT2A 288/4885KCNH2 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.