Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 12/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21411397 | 0.89 | HDAC1 (0.38) | KDM4EALDH1A1LMNAMAPTGAA | |
| SCHEMBL4169623 | 0.80 | RAF1 (0.44) | KDM4ERAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL4769749 | 0.78 | RAF1 (0.43) | KDM4ERAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL19687669 | 0.77 | RAF1 (0.42) | KDM4ERAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL30143824 | 0.73 | KDM4A (0.39) | KDM4EALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL26577880 | 0.72 | KDM4A (0.38) | KDM4ELMNAGAAL3MBTL1KDM4A | |
| SCHEMBL13425471 | 0.72 | RAF1 (0.65) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8255339 | 0.71 | HPGD (0.48) | ALDH1A1LMNAMAPTHPGDPPARG | |
| SCHEMBL667203 | 0.71 | RAF1 (0.61) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL101455 | 0.71 | RAF1 (0.42) | KDM4EALDH1A1LMNAMAPTRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774815-A1 | THIENOPYRIMIDINONE COMPOUNDS | Biotheryx Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| CN-112313236-A | Thienopyrimidinone compounds | 拜欧斯瑞克斯公司 | 2021-02-02 | — | — | CN | disclosed |
| US-10584133-B2 | Thienopyrimidinone compounds | BIOTHERYX, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190322682-A1 | THIENOPYRIMIDINONE COMPOUNDS | BIOTHERYX, INC. | 2019-10-24 | — | — | US | disclosed |
| WO-2019191451-A1 | THIENOPYRIMIDINONE COMPOUNDS | BIOTHERYX, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322682-A1 | THIENOPYRIMIDINONE COMPOUNDS | MAVS, BRCA1, HSPE1 | KDM4E 2951/4885ALDH1A1 4147/4885LMNA 2974/4885 |
| US-10584133-B2 | Thienopyrimidinone compounds | MAVS, BRCA1, HSPE1 | KDM4E 2951/4885ALDH1A1 4147/4885LMNA 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.