Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 16/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21413003 | 0.85 | TRPA1 (0.52) | TRPA1 | |
| SCHEMBL18545335 | 0.84 | TRPA1 (0.35) | TRPA1DYRK1A | |
| SCHEMBL21412998 | 0.83 | TRPA1 (0.42) | TRPA1WNT1GSK3BDYRK1A | |
| SCHEMBL17205160 | 0.80 | TRPA1 (0.57) | TRPA1 | |
| SCHEMBL17204949 | 0.78 | TRPA1 (0.42) | TRPA1WNT1GSK3BDYRK1A | |
| SCHEMBL17205457 | 0.78 | TRPA1 (0.59) | TRPA1 | |
| SCHEMBL18539052 | 0.78 | TRPA1 (0.59) | TRPA1 | |
| SCHEMBL17205449 | 0.77 | TRPA1 (0.48) | TRPA1 | |
| SCHEMBL21413005 | 0.76 | GRM5 (0.37) | TRPA1 | |
| SCHEMBL17205350 | 0.76 | TRPA1 (0.44) | TRPA1WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428072-B2 | Inhibiting the transient receptor potential A1 ion channel | ELI LILLY AND COMPANY (US) | 2019-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428072-B2 | Inhibiting the transient receptor potential A1 ion channel | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885WNT1 1542/4885GSK3B 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.