Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17695823 | 0.89 | RORC (0.54) | RORCPHGDH | |
| SCHEMBL21415753 | 0.89 | RORC (0.54) | RORCPHGDH | |
| SCHEMBL17695899 | 0.82 | RORC (0.56) | RORCPHGDH | |
| SCHEMBL21415856 | 0.82 | RORC (0.56) | RORCPHGDH | |
| SCHEMBL17695826 | 0.81 | RORC (0.65) | RORC | |
| SCHEMBL21415767 | 0.81 | RORC (0.65) | RORC | |
| SCHEMBL21415918 | 0.80 | RORC (0.56) | RORC | |
| SCHEMBL17695961 | 0.80 | RORC (0.56) | RORC | |
| SCHEMBL23343581 | 0.79 | RORC (0.53) | RORC | |
| SCHEMBL23343597 | 0.78 | RORC (0.53) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207043-B3 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS LLC (US) | 2019-10-02 | — | — | EP | disclosed |