Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21415753 | 1.00 | RORC (0.54) | RORCROCK2PHGDH | |
| SCHEMBL17695826 | 0.91 | RORC (0.65) | RORC | |
| SCHEMBL21415767 | 0.91 | RORC (0.65) | RORC | |
| SCHEMBL21415765 | 0.89 | RORC (0.44) | RORCPHGDH | |
| SCHEMBL17695961 | 0.88 | RORC (0.56) | RORC | |
| SCHEMBL21415918 | 0.88 | RORC (0.56) | RORC | |
| SCHEMBL21415902 | 0.86 | RORC (0.47) | RORCROCK2 | |
| SCHEMBL21415814 | 0.85 | RORC (0.47) | RORCROCK2 | |
| SCHEMBL21415856 | 0.84 | RORC (0.56) | RORCPHGDH | |
| SCHEMBL17695899 | 0.84 | RORC (0.56) | RORCPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222902-A1 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, LLC | 2018-08-09 | — | — | US | disclosed |
| WO-2016061160-A1 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, INC. (US) | 2016-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222902-A1 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | RORC, RORB, RORA | RORC 1/4885ROCK2 2088/4885PHGDH 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.