Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21415749 | 0.90 | RORC (0.48) | RORCROCK2ROCK1MAPK1 | |
| SCHEMBL21415871 | 0.90 | RORC (0.48) | RORCROCK2ROCK1MAPK1 | |
| SCHEMBL21415858 | 0.88 | RORC (0.41) | RORCROCK2ROCK1 | |
| SCHEMBL21415753 | 0.86 | RORC (0.54) | RORCROCK2 | |
| SCHEMBL21787414 | 0.86 | RORC (0.48) | RORCROCK2ROCK1MAPK1 | |
| SCHEMBL17695823 | 0.86 | RORC (0.54) | RORCROCK2 | |
| SCHEMBL21415814 | 0.85 | RORC (0.47) | RORCROCK2ROCK1MAPK1 | |
| SCHEMBL21415767 | 0.85 | RORC (0.65) | RORC | |
| SCHEMBL17695826 | 0.85 | RORC (0.65) | RORC | |
| SCHEMBL21415844 | 0.83 | RORC (0.48) | RORCROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207043-B3 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS LLC (US) | 2019-10-02 | — | — | EP | disclosed |