Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184649 | 0.81 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL2235637 | 0.76 | CYP1A2 (0.55) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL356011 | 0.76 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL16060789 | 0.74 | KDM4E (0.57) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL14568587 | 0.74 | CFTR (0.51) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL5502180 | 0.73 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL115650 | 0.73 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL356336 | 0.73 | L3MBTL1 (0.51) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL11874548 | 0.73 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL5493842 | 0.72 | SMN1; SMN2 (0.59) | MAPTALDH1A1KDM4EL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |