Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPRA | P18433 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032520 | 0.84 | CNR2 (0.42) | KMT2ACNR1CNR2 | |
| SCHEMBL17710046 | 0.83 | RIPK1 (0.49) | LMNARIPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4768519 | 0.82 | KMT2A (0.45) | PTPRBLMNAKMT2ASMN1; SMN2PTPN1 | |
| SCHEMBL19182702 | 0.79 | KDM4E (0.41) | LMNAKMT2ASMN1; SMN2RIPK1PIM1 | |
| SCHEMBL11509018 | 0.79 | PTPRB (0.47) | PTPRBPTPN1PTPN2PTPRAMMP8 | |
| SCHEMBL5198639 | 0.77 | RIPK1 (0.45) | RIPK1 | |
| SCHEMBL20032507 | 0.76 | CYP4A11 (0.45) | CNR1CNR2 | |
| SCHEMBL20032506 | 0.76 | CYP4A11 (0.45) | CNR1CNR2 | |
| SCHEMBL15448872 | 0.76 | S100A9 (0.35) | LMNAKMT2AHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL11648125 | 0.75 | PTGS1 (0.44) | PTPRBLMNAKMT2ASMN1; SMN2PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519423-B1 | ENDOSOMOLYTIC AGENTS FOR GENE THERAPY | UCB Biopharma SRL (BE) | 2021-04-07 | — | — | EP | disclosed |
| US-10842884-B2 | Endosomolytic agents for gene therapy | UCB Biopharma SRL (BE) | 2020-11-24 | — | — | US | disclosed |
| US-20190298859-A1 | Endosomolytic Agents for Gene Therapy | UCB BIOPHARMA SRL (UCB BIOPHARMA SOCIETE A RESPONSABILITE LIMITEE) (BE) | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10842884-B2 | Endosomolytic agents for gene therapy | YARS1, ARSA, RPS6 | NOTUM 4201/4885PTPRB 721/4885LMNA 2997/4885 |
| US-20190298859-A1 | Endosomolytic Agents for Gene Therapy | YARS1, ARSA, RPS6 | NOTUM 4201/4885PTPRB 721/4885LMNA 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.