Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | PYGM | P11217 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21425701 | 0.88 | TGFBR1 (0.49) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL21425598 | 0.87 | TGFBR1 (0.39) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL21425528 | 0.85 | TGFBR1 (0.53) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL21425594 | 0.84 | KDR (0.52) | TGFBR1GRM5CSF1R | |
| SCHEMBL3947048 | 0.79 | TGFBR1 (0.53) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL21425632 | 0.75 | TGFBR1 (0.46) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL21408144 | 0.75 | KDM4E (0.42) | TGFBR1CSF1RPDGFRBPDGFRAPYGL | |
| SCHEMBL21425527 | 0.73 | TGFBR1 (0.43) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL30890837 | 0.73 | TGFBR1 (0.43) | TGFBR1GRM5CSF1RPDGFRBPDGFRA | |
| SCHEMBL16211028 | 0.73 | CCR1 (0.52) | GRM5PYGLPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632907-B1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2024-02-28 | — | — | EP | disclosed |
| EP-3632907-A1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |