Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 4/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21851749 | 0.87 | TGFBR1 (0.36) | TGFBR1KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL22186884 | 0.79 | TGFBR1 (0.36) | TGFBR1GRM5 | |
| SCHEMBL21882310 | 0.78 | CSF1R (0.34) | TGFBR1KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL21425594 | 0.78 | KDR (0.52) | TGFBR1KDRCSF1RGRM5BRAF | |
| SCHEMBL21425572 | 0.77 | CSF1R (0.35) | TGFBR1KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL21425528 | 0.77 | TGFBR1 (0.53) | TGFBR1CSF1RPDGFRBPDGFRAGRM5 | |
| SCHEMBL21425701 | 0.76 | TGFBR1 (0.49) | TGFBR1CSF1RPDGFRBPDGFRAGRM5 | |
| SCHEMBL21882349 | 0.76 | TGFBR1 (0.38) | TGFBR1CSF1RPDGFRBPDGFRA | |
| SCHEMBL21425599 | 0.75 | TGFBR1 (0.48) | TGFBR1CSF1RPDGFRBPDGFRAGRM5 | |
| SCHEMBL26944765 | 0.74 | CSF1R (0.42) | KDRCSF1RPDGFRBPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |