Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26321195 | 0.89 | KDM4E (0.51) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8131731 | 0.89 | PDGFRB (0.51) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL18863803 | 0.85 | PDGFRB (0.51) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2722464 | 0.85 | PDGFRB (0.51) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL13516231 | 0.84 | PDGFRB (0.62) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL11397555 | 0.84 | KDM4E (0.53) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL23094629 | 0.83 | PDGFRB (0.47) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1509515 | 0.83 | PDGFRB (0.47) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL4854781 | 0.83 | GAA (0.59) | GAAPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL15822217 | 0.83 | MEN1 (0.48) | GAAPDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024041609-A1 | BENZO BICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 广州市联瑞制药有限公司 | 2024-02-29 | — | — | WO | disclosed |
| US-8519149-B2 | Tricyclic compounds as mPGES-1 inhibitors | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-08-27 | — | — | US | disclosed |
| WO-2012055995-A1 | TRICYCLIC COMPOUNDS AS MPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-05-03 | — | — | WO | disclosed |
| US-20120108583-A1 | Tricyclic Compounds As mPGES-1 Inhibitors | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-05-03 | — | — | US | disclosed |
| US-20120101157-A1 | 4,5-Diamino-3-Halo-2-Hydroxybenzoic Acid Derivatives and Preparations Thereof | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2012-04-26 | — | — | US | disclosed |
| EP-0196910-B1 | Benzo[a]phenazine derivatives | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1991-01-02 | — | — | EP | disclosed |
| US-4686292-A | Benzo[α]phenazine antitumor agents | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1987-08-11 | — | — | US | disclosed |
| EP-0196910-A2 | Benzo[a]phenazine derivatives | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1986-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108583-A1 | Tricyclic Compounds As mPGES-1 Inhibitors | PTGES, PTGS1, PTGIS | GAA 1542/4885PDGFRB 3061/4885FGFR1 1902/4885 |
| US-20120101157-A1 | 4,5-Diamino-3-Halo-2-Hydroxybenzoic Acid Derivatives and Preparations Thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRH3, HRH2 | GAA 152/4885PDGFRB 829/4885FGFR1 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.