Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22732600 | 1.00 | JAK3 (0.42) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL21430657 | 1.00 | JAK3 (0.42) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL13783473 | 0.86 | MEN1 (0.42) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL22732723 | 0.86 | MEN1 (0.42) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL3399184 | 0.82 | MEN1 (0.44) | ALDH1A1LMNAITGB3ITGA2BMEN1 | |
| SCHEMBL21430433 | 0.82 | ITGB3 (0.41) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL15808629 | 0.82 | KDM1A (0.45) | ALDH1A1LMNAITGB3ITGA2BMEN1 | |
| SCHEMBL15808534 | 0.81 | KDM1A (0.45) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL15808519 | 0.81 | KDM1A (0.45) | JAK3JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL23710028 | 0.81 | ITGB3 (0.43) | JAK3JAK2JAK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019185025-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | 正大天晴药业集团股份有限公司 | 2019-10-03 | — | — | WO | disclosed |