Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23710028 | 0.87 | ITGB3 (0.43) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL24171102 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL24171116 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL24170958 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL22732723 | 0.83 | MEN1 (0.42) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL13783473 | 0.83 | MEN1 (0.42) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL15491224 | 0.83 | ITGB3 (0.43) | ITGB3ITGA2BALDH1A1JAK1KDM4E | |
| SCHEMBL22732600 | 0.82 | JAK3 (0.42) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL21430657 | 0.82 | JAK3 (0.42) | ITGB3ITGA2BALDH1A1JAK2JAK1 | |
| SCHEMBL21430432 | 0.82 | JAK3 (0.42) | ITGB3ITGA2BALDH1A1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019185025-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | 正大天晴药业集团股份有限公司 | 2019-10-03 | — | — | WO | disclosed |