Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30525832 | 1.00 | NR1H4 (0.50) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435594 | 1.00 | NR1H4 (0.50) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435591 | 1.00 | NR1H4 (0.50) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435595 | 0.79 | NR1H4 (0.46) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435593 | 0.79 | NR1H4 (0.46) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435590 | 0.79 | NR1H4 (0.46) | NR1H4CHRNA7MEN1KMT2A | |
| SCHEMBL21435654 | 0.78 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL23736424 | 0.77 | NR1H4 (0.52) | NR1H4 | |
| SCHEMBL21456720 | 0.77 | NR1H4 (0.52) | NR1H4 | |
| SCHEMBL23736425 | 0.77 | NR1H4 (0.52) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | ARDELYX, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-20210300927-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | ARDELYX, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-11091482-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | ARDELYX, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| US-20190308973-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | ARDELYX, INC. | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091482-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | FXR1, FXR2, NR1H4 | NR1H4 3/4885CHRNA7 2920/4885MEN1 2098/4885 |
| US-20190308973-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | FXR1, FXR2, NR1H4 | NR1H4 3/4885CHRNA7 2920/4885MEN1 2098/4885 |
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | FXR1, FXR2, NR1H4 | NR1H4 3/4885CHRNA7 2920/4885MEN1 2098/4885 |
| US-20210300927-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | FXR1, FXR2, NR1H4 | NR1H4 3/4885CHRNA7 2920/4885MEN1 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.