Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | AQP1 | P29972 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 16/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21454165 | 1.00 | KDM4E (0.52) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL21436750 | 1.00 | KDM4E (0.52) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL572924 | 0.85 | KDM4E (0.59) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL572925 | 0.85 | KDM4E (0.59) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL10222976 | 0.85 | KDM4E (0.59) | KDM4EUSP2ALDH1A1CA2LMNA | |
| Hydrochloric Acid SCHEMBL21436702 | 0.85 | KDM4E (0.44) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL22922713 | 0.83 | NPSR1 (0.43) | KDM4EUSP2ALDH1A1CA2LMNA | |
| Hydrochloric Acid SCHEMBL21436703 | 0.83 | NPSR1 (0.42) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL574557 | 0.82 | CA2 (0.74) | KDM4EUSP2ALDH1A1CA2LMNA | |
| SCHEMBL21436494 | 0.75 | HPGD (0.41) | KDM4EUSP2ALDH1A1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774763-A1 | BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS | ZILENTIN AG (CH) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019193159-A1 | BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS | Universität Wien (AT) | 2019-10-10 | — | — | WO | disclosed |