Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AQP1 | P29972 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21436703 | 0.99 | NPSR1 (0.42) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| Hydrochloric Acid SCHEMBL21436702 | 0.86 | KDM4E (0.44) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL21436675 | 0.85 | KDM4E (0.59) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL21436750 | 0.83 | KDM4E (0.52) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL21436751 | 0.83 | KDM4E (0.52) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL21454165 | 0.83 | KDM4E (0.52) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL572925 | 0.77 | KDM4E (0.59) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL10222976 | 0.77 | KDM4E (0.59) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL572924 | 0.77 | KDM4E (0.59) | NPSR1KDM4EUSP2ALDH1A1CA2 | |
| SCHEMBL11371169 | 0.74 | CA2 (0.68) | NPSR1KDM4EUSP2ALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210022978-A1 | BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS | Zilentin AG (CH) | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210022978-A1 | BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS | SLC9A1, SLC9A3, SLC5A1 | NPSR1 294/4885KDM4E 3838/4885USP2 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.