Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.59 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.57 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KDM5C | P41229 | 3/20 | 0.48 |
| ▸ | KDM6B | O15054 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1352410 | 0.88 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL27365744 | 0.88 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL1352409 | 0.88 | — | — | |
| Levulinic Acid SCHEMBL357249 | 0.87 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Glutarate SCHEMBL105858 | 0.86 | SLC22A6 (0.73) | LMNATSHRSLC22A6OR51E2ALDH1A1 | |
| Adipic Acid SCHEMBL106657 | 0.86 | LMNA (0.73) | LMNATSHRSLC22A6OR51E2ALDH1A1 | |
| Glutarate SCHEMBL104189 | 0.86 | SLC22A6 (0.73) | LMNATSHRSLC22A6OR51E2ALDH1A1 | |
| Adipic Acid SCHEMBL109249 | 0.86 | LMNA (0.73) | LMNATSHRSLC22A6OR51E2ALDH1A1 | |
| Succinic Acid SCHEMBL105516 | 0.85 | LMNA (0.50) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL3628497 | 0.84 | EGLN1 (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476843-A | Composition comprising silicone compounds and the method using the composition | 美利肯公司 | 2019-03-15 | — | — | CN | claimed |
| US-11884769-B2 | Polyurethane foam forming compositions | SOUDAL (BE) | 2024-01-30 | — | — | US | disclosed |
| EP-3774968-B1 | POLYURETHANE FOAM FORMING COMPOSITIONS | SOUDAL (BE) | 2022-08-17 | — | — | EP | disclosed |
| US-20210155740-A1 | POLYURETHANE FOAM FORMING COMPOSITIONS | SOUDAL (BE) | 2021-05-27 | — | — | US | disclosed |
| EP-3774968-A1 | POLYURETHANE FOAM FORMING COMPOSITIONS | SOUDAL (BE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019193178-A1 | POLYURETHANE FOAM FORMING COMPOSITIONS | SOUDAL (BE) | 2019-10-10 | — | — | WO | disclosed |
| CN-109476843-A | Composition comprising silicone compounds and the method using the composition | 美利肯公司 | 2019-03-15 | — | — | CN | disclosed |