Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302950 | 0.88 | NPSR1 (0.43) | JAK2JAK3PTK2DHODHKCNH3 | |
| SCHEMBL13392080 | 0.84 | KCNH3 (0.54) | JAK2JAK3PTK2DHODHKCNH3 | |
| SCHEMBL14457344 | 0.84 | JAK2 (0.44) | JAK2JAK3PTK2DHODHKCNH3 | |
| SCHEMBL2144674 | 0.80 | KCNH3 (0.45) | JAK2JAK3PTK2KCNH3JAK1 | |
| SCHEMBL2144963 | 0.80 | KCNH3 (0.45) | JAK2JAK3PTK2KCNH3JAK1 | |
| SCHEMBL2145112 | 0.80 | KCNH3 (0.45) | JAK2JAK3PTK2KCNH3JAK1 | |
| SCHEMBL3299482 | 0.80 | JAK2 (0.48) | JAK2JAK3PTK2KCNH3JAK1 | |
| SCHEMBL2144076 | 0.80 | JAK2 (0.48) | JAK2JAK3PTK2KCNH3JAK1 | |
| SCHEMBL14457373 | 0.79 | KCNH3 (0.43) | JAK2JAK3PTK2KCNH3BRAF | |
| SCHEMBL14457330 | 0.78 | CTSS (0.52) | JAK2JAK3PTK2JAK1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |