Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13694257 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL15596801 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL15566236 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL15596703 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL16901922 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL18672266 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL21442599 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL16901882 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL15565441 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNANPSR1HPGDHTT | |
| SCHEMBL9233810 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNANPSR1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653621-A1 | APPARATUS FOR SYNTHESIZING THE IMAGING AGENT 4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-[[4-[[2-(FLUORO-[18F])ETHOXY]METHYL]PHENYL]METHOXY]-3(2H)-PYRIDAZINONE (FLUORPIRIDAZ [18F]) | Lantheus Medical Imaging, Inc. (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2882719-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS IMAGING AGENTS FOR DETECTING MYOCARDIAL PERFUSION | LANTHEUS MEDICAL IMAGING INC (US) | 2019-10-09 | — | — | EP | disclosed |