Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164199 | 0.81 | HDAC1 (0.52) | HDAC3HDAC1GAAL3MBTL1HTT | |
| SCHEMBL18256258 | 0.81 | HTT (0.50) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL21442788 | 0.79 | HDAC1 (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL18256223 | 0.78 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL22587392 | 0.77 | ALDH1A1 (0.66) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL15938644 | 0.77 | TGM2 (0.54) | HDAC3HDAC1HDAC2GAATP53 | |
| SCHEMBL7522106 | 0.77 | GAA (0.67) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL3235344 | 0.76 | HDAC1 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| Hydrochloric Acid SCHEMBL18249511 | 0.76 | TGM2 (0.53) | HDAC3HDAC1HDAC2GAASMN1; SMN2 | |
| SCHEMBL28997137 | 0.75 | POLB (0.62) | HDAC3HDAC1HDAC2HDAC10HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310777-B1 | DIAMIDE MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-09 | — | — | EP | disclosed |