Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12309456 | 0.75 | CD274 (0.48) | CD274PDCD1 | |
| SCHEMBL28047702 | 0.73 | CD274 (0.57) | PTPN1CD274PDCD1 | |
| SCHEMBL28047711 | 0.73 | PTPN1 (0.49) | PTPN1CD274PDCD1 | |
| SCHEMBL28047704 | 0.73 | CD274 (0.57) | PTPN1CD274PDCD1 | |
| SCHEMBL28047708 | 0.73 | PTPN1 (0.49) | PTPN1CD274PDCD1 | |
| SCHEMBL28915772 | 0.73 | APLNR (0.57) | PTPN1APLNRDHFR | |
| SCHEMBL13814620 | 0.71 | PTPN1 (0.49) | PTPN1APLNRCD274DHFR | |
| SCHEMBL28047726 | 0.70 | PTPN1 (0.49) | PTPN1CD274PDCD1 | |
| SCHEMBL28047731 | 0.70 | PTPN1 (0.49) | PTPN1CD274PDCD1 | |
| SCHEMBL22634028 | 0.70 | PTPN1 (0.47) | PTPN1APLNRDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3231798-B1 | THIAZOLE INTERMEDIATES USEFUL IN THE PREPARATION OF RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |