Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15724922 | 0.91 | GLS (0.50) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL21360271 | 0.83 | GLS (0.42) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL21443408 | 0.78 | GLS (0.67) | GLS | |
| SCHEMBL14987004 | 0.68 | GLS (0.67) | GLSALDH1A1 | |
| SCHEMBL14987001 | 0.67 | GLS (0.89) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15727744 | 0.67 | GLS (0.89) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15727751 | 0.66 | GLS (0.65) | GLSALDH1A1RAB9AHSD17B10TSHR | |
| SCHEMBL24800395 | 0.66 | HPGD (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL15725047 | 0.65 | ALDH1A1 (0.63) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL15725232 | 0.65 | ALDH1A1 (0.63) | GLSALDH1A1SMN1; SMN2RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922832-B1 | GLUTAMINASE INHIBITORS AND METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |