SCHEMBL2144573

SCHEMBL2144573

COC(=O)/C=C/C(=O)O[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.46
NFE2L2 Q16236 2/20 0.46
KEAP1 Q14145 1/20 0.46
HTT P42858 3/20 0.44
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.44
KDM4E B2RXH2 3/20 0.42
LMNA P02545 2/20 0.42
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
TYR P14679 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
TSHR P16473 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
IP6K1 Q92551 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2144436 1.00 HCAR2 (0.46) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL2144442 1.00 HCAR2 (0.46) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL2143970 0.84 HCAR2 (0.45) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL560290 0.80 HCAR2 (0.41) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL560289 0.80 HCAR2 (0.41) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL560450 0.80 HCAR2 (0.41) HCAR2NFE2L2KEAP1HTTALDH1A1
SCHEMBL4645426 0.79 MAPT (0.41) HCAR2ALDH1A1MAPTKDM4ELMNA
SCHEMBL28365580 0.76 MAPT (0.41) HCAR2HTTALDH1A1MAPTKDM4E
SCHEMBL5142114 0.76 THRB (0.43) ALDH1A1MAPTKDM4ELMNAKMT2A
SCHEMBL6423031 0.76 ZDHHC2 (0.44) HCAR2NFE2L2KEAP1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2348077-B1 Antifouling composition JOTUN AS (NO) 2013-04-03 EP disclosed
EP-2348077-A1 Antifouling composition Jotun A/S (NO) 2011-07-27 EP disclosed
EP-0802243-B1 Coating composition NOF CORP (JP) 2001-06-27 EP disclosed
US-5795374-A SILYL ACRYLATE POLYMERS NOF CORPORATION (JP) 1998-08-18 US disclosed
EP-0802243-A2 Coating composition NOF CORPORATION (JP) 1997-10-22 EP disclosed