SCHEMBL21445784

SCHEMBL21445784

Cc1nc(-c2ccc(OCC(C)C)c(C#N)c2)sc1CO

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.71
ABCC4 O15439 1/20 0.71
ABCB11 O95342 1/20 0.71
PGR P06401 1/20 0.71
CHRM1 P11229 1/20 0.71
PDE4A P27815 1/20 0.71
BLVRB P30043 1/20 0.71
TARBP2 Q15633 1/20 0.71
HDAC6 Q9UBN7 1/20 0.71
ABCG2 Q9UNQ0 1/20 0.71
PPID Q08752 1/20 0.56
S1PR1 P21453 1/20 0.51
SLC22A12 Q96S37 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31421717 1.00 XDH (0.71) XDHABCC4ABCB11PGRCHRM1
Formic Acid SCHEMBL28346472 0.87 XDH (0.68) XDHABCC4ABCB11PGRCHRM1
SCHEMBL28280399 0.87 XDH (0.74) XDHABCC4ABCB11PGRCHRM1
SCHEMBL12133604 0.86 XDH (0.73) XDHABCC4ABCB11PGRCHRM1
SCHEMBL2350350 0.86 XDH (0.72) XDHABCC4ABCB11PGRCHRM1
Febuxostat SCHEMBL29398803 0.83 XDH (1.00) XDHABCC4ABCB11PGRCHRM1
SCHEMBL16363788 0.83 XDH (0.85) XDHABCC4ABCB11PGRCHRM1
Febuxostat SCHEMBL30161803 0.83 XDH (1.00) XDHABCC4ABCB11PGRCHRM1
Febuxostat SCHEMBL28271887 0.83 XDH (1.00) XDHABCC4ABCB11PGRCHRM1
Febuxostat SCHEMBL249339 0.83 XDH (1.00) XDHABCC4ABCB11PGRCHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019193068-A1 A PROCESS FOR THE SYNTHESIS OF CARBON LABELED ORGANIC COMPOUNDS COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) 2019-10-10 WO disclosed