Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19203857 | 0.82 | ALK (0.56) | CCNA2CDK2ALKPTK2AURKA | |
| SCHEMBL19203872 | 0.74 | LRRK2 (0.69) | CDK9ALKPTK2AURKAMAPK9 | |
| SCHEMBL16656851 | 0.73 | INSR (0.60) | ALKAURKAINSR | |
| SCHEMBL15424352 | 0.72 | ALK (0.41) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL1039004 | 0.71 | ALK (0.56) | CCND3ALKPTK2AXLAURKB | |
| SCHEMBL15217781 | 0.71 | ALK (0.62) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL20232208 | 0.70 | BCL6 (0.58) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL21437508 | 0.69 | AXL (0.74) | CDK9ALKPTK2AXLAURKA | |
| SCHEMBL21438066 | 0.69 | AXL (0.73) | ALKPTK2AXLAURKAAURKB | |
| SCHEMBL31173410 | 0.69 | AXL (0.73) | ALKPTK2AXLAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195753-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | TOLERO PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |