Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.68 |
| ▸ | HTR2A | P28223 | 17/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887881 | 0.85 | SLC6A4 (0.68) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5837833 | 0.81 | SLC6A4 (1.00) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5837159 | 0.81 | HTR2A (1.00) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL25512501 | 0.79 | SLC6A4 (0.53) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL1254174 | 0.79 | HTR2A (0.65) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL3761927 | 0.79 | L3MBTL1 (0.54) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL9144848 | 0.79 | ALDH1A1 (0.53) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL419377 | 0.78 | SLC6A4 (0.51) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL24252449 | 0.77 | SLC6A4 (0.46) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL772818 | 0.77 | SLC6A4 (0.46) | SLC6A4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195159-A1 | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2019-10-10 | — | — | WO | disclosed |