SCHEMBL21450022

SCHEMBL21450022

CSC(F)(F)C(=O)Nc1c(F)ccc(NC(=O)c2cc(NC(=O)[C@H]3[C@H](c4ccc(F)c(C(F)(F)F)c4)C3(Cl)Cl)ccc2Cl)c1F

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.36
MEN1 O00255 5/20 0.36
LMNA P02545 3/20 0.36
BRAF P15056 1/20 0.35
ALDH1A1 P00352 2/20 0.35
RECQL P46063 1/20 0.35
MAPT P10636 3/20 0.34
MAPK1 P28482 1/20 0.34
KDM4E B2RXH2 2/20 0.34
GRM4 Q14833 1/20 0.33
TMPRSS4 Q9NRS4 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
TP53 P04637 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PTGES O14684 2/20 0.32
NR1I2 O75469 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25841075 1.00 KMT2A (0.36) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL30739943 0.92 KMT2A (0.37) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20050467 0.92 KMT2A (0.37) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20050643 0.92 KMT2A (0.37) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20901119 0.92 KMT2A (0.38) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20050463 0.92 KMT2A (0.36) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20051199 0.92 KMT2A (0.36) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20901046 0.92 KMT2A (0.38) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20050788 0.92 KMT2A (0.38) KMT2AMEN1LMNABRAFALDH1A1
SCHEMBL20050563 0.92 KMT2A (0.39) KMT2AMEN1LMNABRAFALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3772962-B9 MOLECULES HAVING PESTICIDAL UTILITY, COMPOSITIONS AND PEST CONTROLLING PROCESS RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2023-07-19 EP disclosed
EP-3772962-B1 MOLECULES HAVING PESTICIDAL UTILITY, COMPOSITIONS AND PEST CONTROLLING PROCESS RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2023-05-10 EP disclosed
US-20210015098-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2021-01-21 US disclosed
CN-111698906-A Molecules having pesticidal utility, compositions and pest control methods related thereto 美国陶氏益农公司 2020-09-22 CN disclosed
WO-2019194982-A1 MOLECULES HAVING PESTICIDAL UTILITY, COMPOSITIONS AND PEST CONTROLLING PROCESS RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210015098-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MLYCD KMT2A 2615/4885MEN1 1180/4885LMNA 3364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.