Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 15/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 7/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400442 | 0.89 | CDK1 (1.00) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL17450180 | 0.87 | TDP1 (0.61) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL5196875 | 0.86 | CDK1 (0.83) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL17628615 | 0.84 | CDK1 (0.87) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL5192872 | 0.84 | CDK1 (0.79) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL1443236 | 0.80 | TDP1 (0.80) | CDK1TDP1CDK5CDK2CCNE2 | |
| SCHEMBL8010398 | 0.80 | CDK1 (1.00) | CDK1TDP1KDM4EMAPTCDK5 | |
| SCHEMBL6152647 | 0.79 | CDK1 (0.82) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL1443458 | 0.79 | CDK1 (0.80) | CDK1TDP1KDM4ENPC1MAPT | |
| SCHEMBL3696802 | 0.78 | CDK1 (0.75) | CDK1TDP1KDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10981944-B2 | Modulators of 5′-nucleotidase, ecto and the use thereof | ARCUS BIOSCIENCES, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20190309010-A1 | MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF | ARCUS BIOSCIENCES, INC. | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981944-B2 | Modulators of 5′-nucleotidase, ecto and the use thereof | ENTPD5, NT5C2, NT5E | CDK1 3650/4885TDP1 196/4885KDM4E 2438/4885 |
| US-20190309010-A1 | MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF | ENTPD5, NT5C2, NT5E | CDK1 3655/4885TDP1 196/4885KDM4E 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.