Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 15/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 7/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3851604 | 0.89 | TDP1 (0.78) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL21450119 | 0.87 | CDK1 (0.79) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL17450186 | 0.86 | TDP1 (0.64) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL17442999 | 0.80 | CDK1 (0.73) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL17450224 | 0.80 | CDK1 (0.57) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL3298667 | 0.78 | CDK1 (0.63) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL17450128 | 0.78 | CDK1 (0.60) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL3295958 | 0.78 | CDK2 (0.68) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL3299543 | 0.77 | CDK2 (0.70) | TDP1KDM4ENPC1MAPTCDK1 | |
| SCHEMBL3295975 | 0.76 | CDK2 (0.66) | TDP1KDM4ENPC1MAPTCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10519160-B2 | Imaging agents for neural flux | THE GENERAL HOSPITAL CORPORATION (US) | 2019-12-31 | — | — | US | disclosed |
| WO-2016011394-A1 | IMAGING AGENTS FOR NEURAL FLUX | THE GENERAL HOSPITAL CORPORATION (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10519160-B2 | Imaging agents for neural flux | SLC18A2, SLC18A3, PMP22 | TDP1 1230/4885KDM4E 4777/4885NPC1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.