SCHEMBL21451083

SCHEMBL21451083

O=C(O)CSc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.89
FFAR1 O14842 4/20 0.68
HSD17B10 Q99714 1/20 0.51
LMNA P02545 2/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
PPARG P37231 1/20 0.49
PPARD Q03181 1/20 0.49
PPARA Q07869 1/20 0.49
GAA P10253 1/20 0.49
SRD5A2 P31213 3/20 0.47
CTSB P07858 1/20 0.47
ELANE P08246 1/20 0.47
DUSP3 P51452 1/20 0.47
PARP10 Q53GL7 1/20 0.47
APEX1 P27695 1/20 0.46
MAPT P10636 1/20 0.46
LTA4H P09960 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11540586 0.86 ALDH1A1 (0.83) ALDH1A1FFAR1HSD17B10MEN1KMT2A
SCHEMBL74365 0.82 FFAR1 (1.00) ALDH1A1FFAR1HSD17B10LMNAMEN1
SCHEMBL8000250 0.82 ALDH1A1 (0.75) ALDH1A1FFAR1HSD17B10PPARGPPARD
SCHEMBL15570635 0.80 FFAR1 (0.95) ALDH1A1FFAR1HSD17B10LMNAMEN1
SCHEMBL15572345 0.80 FFAR1 (0.95) ALDH1A1FFAR1HSD17B10MEN1KMT2A
SCHEMBL15571405 0.80 FFAR1 (0.95) ALDH1A1FFAR1HSD17B10LMNAMEN1
SCHEMBL15571433 0.80 FFAR1 (0.95) ALDH1A1FFAR1HSD17B10LMNAMEN1
Ammonia Solution, Strong SCHEMBL6255246 0.80 FFAR1 (0.95) ALDH1A1FFAR1HSD17B10LMNAMEN1
SCHEMBL3149997 0.80 FFAR1 (0.64) ALDH1A1FFAR1LMNAMEN1KMT2A
SCHEMBL4255888 0.79 ALDH1A1 (0.72) ALDH1A1FFAR1HSD17B10LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332476-B2 Fms-like tyrosine kinase inhibitors 3SM BIOTRON INC. (TW) 2022-05-17 US disclosed
US-20200131194-A1 FMS-LIKE TYROSINE KINASE INHIBITORS Sagabio Co., Ltd. (TW) 2020-04-30 US disclosed
WO-2019191896-A1 FMS-LIKE TYROSINE KINASE INHIBITORS 3SM BIOTRON INC. (CN) 2019-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11332476-B2 Fms-like tyrosine kinase inhibitors FLT3, FLT4, FLT1 ALDH1A1 3008/4885FFAR1 1962/4885HSD17B10 4052/4885
US-20200131194-A1 FMS-LIKE TYROSINE KINASE INHIBITORS FLT3, FLT4, FLT1 ALDH1A1 3008/4885FFAR1 1962/4885HSD17B10 4052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.