Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30893601 | 1.00 | KDM1A (0.42) | KDM1ASLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL30893594 | 1.00 | KDM1A (0.42) | KDM1ASLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL23595816 | 1.00 | KDM1A (0.42) | KDM1ASLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL23595773 | 1.00 | KDM1A (0.42) | KDM1ASLC6A4SLC6A3SLC6A2PSEN1 | |
| SCHEMBL23595763 | 0.83 | SLC6A3 (0.43) | KDM1ASLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL21452125 | 0.83 | SLC6A3 (0.43) | KDM1ASLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL23595865 | 0.83 | SLC6A3 (0.43) | KDM1ASLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL23595841 | 0.81 | HDAC4 (0.49) | HSD11B1HSD11B2HTR2AHTR2CGAA | |
| SCHEMBL21452104 | 0.81 | HDAC4 (0.49) | HSD11B1HSD11B2HTR2AHTR2CGAA | |
| SCHEMBL23595798 | 0.81 | HDAC4 (0.49) | HSD11B1HSD11B2HTR2AHTR2CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300886-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2024-09-12 | — | — | US | disclosed |
| US-20240254095-A1 | NMDA Receptor Antagonist and Use Thereof | SYNPHATEC (SHANGHAI) BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2024-08-01 | — | — | US | disclosed |
| EP-4358946-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | Gilgamesh Pharmaceuticals, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| EP-4339189-A1 | NMDA RECEPTOR ANTAGONIST AND USE THEREOF | Synphatec (Shanghai) Biopharmaceutical Technology Co., Ltd. (CN) | 2024-03-20 | — | — | EP | disclosed |
| CN-113234036-B | NMDA receptor antagonists and uses thereof | 斯莱普泰(上海)生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022272174-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022272174-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022237849-A1 | NMDA RECEPTOR ANTAGONIST AND USE THEREOF | 中国科学院上海有机化学研究所 | 2022-11-17 | — | — | WO | disclosed |
| CN-113234036-A | NMDA receptor antagonists and uses thereof | 中国科学院上海有机化学研究所 | 2021-08-10 | — | — | CN | disclosed |
| US-20210171487-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI JIANHE PHARMACEUTICAL & TECHNOLOGY CO. LTD. (CN) | 2021-06-10 | — | — | US | disclosed |
| EP-3778579-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jianhe Pharmaceutical & Technology Co. Ltd. (CN) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019192602-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海键合医药科技有限公司 | 2019-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300886-A1 | ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | HTR2C, PNMT, HTR2A | KDM1A 1549/4885SLC6A4 21/4885SLC6A3 14/4885 |
| US-20240254095-A1 | NMDA Receptor Antagonist and Use Thereof | GRIN2B, GRIN1, GRIN3A | KDM1A 1585/4885SLC6A4 243/4885SLC6A3 177/4885 |
| US-20210171487-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | CYP4F11, PAH, COMT | KDM1A 3700/4885SLC6A4 64/4885SLC6A3 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.