Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.30 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593166 | 0.81 | DAO (0.50) | DAOPDE2AFFAR4KIF11FFAR1 | |
| SCHEMBL15385131 | 0.79 | DAO (0.48) | DAOIDO1PDE2AKIF11 | |
| SCHEMBL590101 | 0.79 | ALDH1A1 (0.39) | AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL22296720 | 0.79 | GLA (0.37) | IDO1PDE2A | |
| Hydrochloric Acid SCHEMBL23165936 | 0.78 | DAO (0.47) | DAOIDO1PDE2AKIF11 | |
| SCHEMBL12886693 | 0.77 | PDE2A (0.53) | DAOIDO1PDE2AFFAR4KIF11 | |
| SCHEMBL13598345 | 0.76 | DAO (0.48) | DAOIDO1PDE2AFFAR4KIF11 | |
| SCHEMBL29277330 | 0.76 | DAO (0.48) | DAOIDO1PDE2AFFAR4KIF11 | |
| SCHEMBL3901935 | 0.76 | KIF11 (0.51) | DAOPDE2AFFAR4KIF11FFAR1 | |
| SCHEMBL11618144 | 0.75 | DAO (0.44) | DAOIDO1PDE2AKIF11RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |