Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 8/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.45 |
| ▸ | ITGAL | P20701 | 6/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434124 | 1.00 | KMO (0.49) | KMOITGB2ICAM1ITGALMALT1 | |
| SCHEMBL21434122 | 1.00 | KMO (0.49) | KMOITGB2ICAM1ITGALMALT1 | |
| SCHEMBL21452657 | 1.00 | KMO (0.49) | KMOITGB2ICAM1ITGALMALT1 | |
| SCHEMBL21433985 | 0.92 | ITGB2 (0.46) | KMOITGB2ICAM1ITGALABL1 | |
| SCHEMBL21452347 | 0.92 | ITGB2 (0.46) | KMOITGB2ICAM1ITGALABL1 | |
| SCHEMBL21434008 | 0.92 | ITGB2 (0.46) | KMOITGB2ICAM1ITGALABL1 | |
| SCHEMBL21433982 | 0.92 | ITGB2 (0.46) | KMOITGB2ICAM1ITGALABL1 | |
| SCHEMBL21452604 | 0.92 | ITGB2 (0.46) | KMOITGB2ICAM1ITGALABL1 | |
| SCHEMBL21434129 | 0.91 | ITGB2 (0.45) | KMOITGB2ICAM1ITGALSSTR1 | |
| SCHEMBL21434131 | 0.91 | ITGB2 (0.45) | KMOITGB2ICAM1ITGALSSTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |