SCHEMBL21453590

SCHEMBL21453590

c1cc(-c2ccc3c(c2)c2cccc4c5ccccc5c5ccccc5c5ccccc5n3c42)cc(-c2cc3ccccc3c3ccccc23)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.40
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
HSD17B10 Q99714 2/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
CASP1 P29466 1/20 0.35
HIF1A Q16665 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KDM4E B2RXH2 3/20 0.34
MEN1 O00255 3/20 0.34
MAPT P10636 3/20 0.34
KMT2A Q03164 3/20 0.34
POLB P06746 2/20 0.34
HTT P42858 1/20 0.34
TSPO P30536 1/20 0.34
MPI P34949 1/20 0.33
NPY5R Q15761 2/20 0.32
HSD17B1 P14061 2/20 0.32
HSD17B2 P37059 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10015060 0.92 CYP11B1 (0.42) CYP11B1ALDH1A1HPGDHSD17B10TSHR
SCHEMBL21453791 0.89 ALDH1A1 (0.34) CYP11B1ALDH1A1HPGDHSD17B10TSHR
SCHEMBL15460080 0.89 CYP11B1 (0.40) CYP11B1ALDH1A1HPGDHSD17B10TSHR
SCHEMBL15460069 0.87 CA12 (0.42) ALDH1A1HPGDKDM4EMEN1MAPT
SCHEMBL15460063 0.87 HSD17B1 (0.39) ALDH1A1HPGDHSD17B10TSHRHIF1A
SCHEMBL21454108 0.86 ALDH1A1 (0.33) CYP11B1ALDH1A1HPGDHSD17B10TSHR
SCHEMBL21453578 0.85 KDM4E (0.39) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL17994993 0.85 KDM4E (0.39) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL17995383 0.85 KDM4E (0.39) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL15460075 0.84 HSD17B1 (0.47) CYP11B1ALDH1A1HPGDKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L CYP11B1 290/4885ALDH1A1 802/4885HPGD 830/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L CYP11B1 290/4885ALDH1A1 802/4885HPGD 830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.