SCHEMBL21453596

SCHEMBL21453596

c1ccc2c(-c3c4ccccc4c(-c4ccc5c(c4)c4cccc6c7ccccc7c7ccccc7c7ccccc7n5c64)c4ccccc34)cccc2c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 3/20 0.36
BMX P51813 2/20 0.36
POLB P06746 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 1/20 0.34
TUBB4A P04350 1/20 0.34
TUBB P07437 1/20 0.34
TUBA3C P0DPH7 1/20 0.34
TUBA1B P68363 1/20 0.34
TUBA4A P68366 1/20 0.34
TUBB4B P68371 1/20 0.34
TUBB3 Q13509 1/20 0.34
TUBB2A Q13885 1/20 0.34
TUBB8 Q3ZCM7 1/20 0.34
TUBA3E Q6PEY2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453589 0.96 CA12 (0.36) FLT3BMXPOLBKDM4EMEN1
SCHEMBL19863137 0.92 FLT3 (0.36) FLT3BMXPOLBKDM4EMEN1
SCHEMBL21453796 0.88 FLT3 (0.32) FLT3BMXPTGESCA12CA1
SCHEMBL26222089 0.86 MCL1 (0.36) FLT3BMXMCL1ACMSDCA12
SCHEMBL21454109 0.86 FLT3 (0.31) FLT3BMX
SCHEMBL21453597 0.86 HSD17B1 (0.39) POLBKDM4EMEN1ALDH1A1MAPT
SCHEMBL25514033 0.85 NTSR1 (0.36) FLT3BMXMCL1ACMSDCA12
SCHEMBL21454112 0.85 CA12 (0.31) FLT3BMXCA12CA1CA2
SCHEMBL15460069 0.84 CA12 (0.42) FLT3BMXPOLBKDM4EMEN1
SCHEMBL21453844 0.84 FLT3 (0.30) FLT3BMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L FLT3 3626/4885BMX 3259/4885POLB 3689/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L FLT3 3626/4885BMX 3259/4885POLB 3689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.