5-Fluorouridine

5-Fluorouridine

SCHEMBL214536

O=c1[nH]c(=O)n([C@H]2O[C@@H](CO)C(O)C2O)cc1F

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PYGM P11217 3/20 0.70
LMNA P02545 2/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
TSHR P16473 1/20 0.67
MAPT P10636 1/20 0.67
PMP22 Q01453 1/20 0.67
HBB P68871 1/20 0.67
TK2 O00142 2/20 0.65
P2RY6 Q15077 2/20 0.64
P2RY14 Q15391 2/20 0.64
NT5E P21589 1/20 0.64
SLC28A1 O00337 1/20 0.60
SLC28A2 O43868 1/20 0.60
SLC29A1 Q99808 1/20 0.60
SLC28A3 Q9HAS3 1/20 0.60
P2RY2 P41231 3/20 0.53
DNPH1 O43598 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Fluorouridine SCHEMBL329747 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL19901621 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL1682759 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL3385435 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL12174049 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL329381 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL17173362 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL11756887 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL21423048 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT
5-Fluorouridine SCHEMBL2584234 1.00 PYGM (0.70) PYGMLMNASMN1; SMN2TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630985-B1 SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS ARCTURUS THERAPEUTICS INC (US) 2025-08-27 EP claimed
CN-110719954-B Therapeutic agent for glycogen storage disease type III 奥特吉尼克斯制药公司 2023-12-26 CN claimed
EP-3191114-B1 OCCIDIOFUNGIN FORMULATIONS AND USES THEREOF UNIV MISSISSIPPI STATE (US) 2021-03-03 EP claimed
US-10247732-B2 Materials and methods for diagnosing and predicting the course of prostate cancer INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2019-04-02 US claimed
EP-2488182-B1 Treating neurotoxicity associated with combinations of 5-FU or its prodrugs and DPD inhibitors ELION ONCOLOGY LLC (US) 2017-07-19 EP claimed
EP-2476707-B1 Self-cleaving ribozymes and uses thereof CHILDREN'S MEDICAL CENTER CORP (US) 2017-05-24 EP claimed
US-20170030916-A1 MATERIALS AND METHODS FOR DIAGNOSING AND PREDICTING THE COURSE OF PROSTATE CANCER UNIV INDIANA RES & TECH CORP (US) 2017-02-02 US claimed
EP-2475674-B1 PROBES COMPRISING FLUORESCENT ARTIFICIAL NUCLEOBASES AND USE THEREOF FOR DETECTION OF SINGLE BASE ALTERATION HUMBOLDT UNIVERSITÄT ZU BERLIN (DE) 2017-01-25 EP claimed
EP-2012799-B1 METABOLICALLY STABLE ALKOXYALKYL ESTERS OF ANTIVIRAL OR ANTIPROLIFERATIVE PHOSPHONATES, NUCLEOSIDE PHOSPHONATES AND NUCLEOSIDE PHOSPHATES CHIMERIX INC (US) 2016-08-24 EP claimed
EP-2308885-B1 Novel compounds and methods for therapy GILEAD SCIENCES INC (US) 2014-11-19 EP claimed
EP-0989847-A1 ANTI-TUMORAL THERAPY AGENT MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (DE) 2000-04-05 EP claimed
WO-1998055103-A9 ANTI-TUMORAL THERAPY AGENT MAX DELBRUECK CENTRUM (DE) 1999-04-08 WO claimed
EP-0741740-B1 METHOD OF PREPARING UNSYMMETRICAL PHOSPHORIC ACID DIESTERS AND SALTS ROCHE DIAGNOSTICS GMBH (DE) 1999-04-07 EP claimed
WO-1998055103-A1 ANTI-TUMORAL THERAPY AGENT Max-Delbrück-Centrum für Molekulare Medizin (DE) 1998-12-10 WO claimed
EP-0653439-A2 Stabilized oligonucleotids and the use thereof HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-17 EP claimed
EP-0595133-A2 Prodrugs, their preparation and use as medicaments BEHRINGWERKE Aktiengesellschaft (DE) 1994-05-04 EP claimed
EP-0262876-B1 NUCLEOSIDE-PHOSPHOLIPID CONJUGATE TOYO JOZO KABUSHIKI KAISHA (JP) 1992-04-29 EP claimed
EP-0180188-B1 A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1992-04-15 EP claimed
US-5051499-A Phosphatides as antitumor agents TOYO JOZO KABUSHIKI KAISHA (JP) 1991-09-24 US claimed
US-4797479-A ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS TOYO JOZO KABUSHIKI KAISHA (JP) 1989-01-10 US claimed