Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | HBB | P68871 | 1/20 | 0.67 |
| ▸ | TK2 | O00142 | 2/20 | 0.65 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.64 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.64 |
| ▸ | NT5E | P21589 | 1/20 | 0.64 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.60 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.60 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.60 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.53 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Fluorouridine SCHEMBL19901621 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL1682759 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL214536 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL3385435 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL12174049 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL329381 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL17173362 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL11756887 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL21423048 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT | |
| 5-Fluorouridine SCHEMBL2584234 | 1.00 | PYGM (0.70) | PYGMLMNASMN1; SMN2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10882903-B2 | Methods and compositions for treating an alphavirus infection | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-01-05 | — | — | US | disclosed |
| US-10869873-B2 | Methods and compositions for treating viral diseases | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-12-22 | — | — | US | disclosed |
| EP-2787999-B1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL DISEASES | UNIV LELAND STANFORD JUNIOR (US) | 2019-01-23 | — | — | EP | disclosed |
| US-20180134778-A1 | METHODS AND COMPOSITIONS FOR TREATING AN ALPHAVIRUS INFECTION | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180000926-A1 | METHODS OF INDUCING AN IMMUNE RESPONSE TO HEPATITIS C VIRUS | AGRAWAL, BABITA (CA) | 2018-01-04 | — | — | US | disclosed |
| US-20170000802-A1 | Methods and Compositions for Treating Viral Diseases | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-01-05 | — | — | US | disclosed |
| CN-103145715-B | Huge ring carboxylic acid and acyl sulfonamides as HCV replication inhibitors | F·霍夫曼-罗须公司 | 2016-08-03 | — | — | CN | disclosed |
| US-9364484-B2 | Methods and compositions for treating viral diseases | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| EP-3025727-A1 | METHODS OF TREATING LIVER DISEASE | The J. David Gladstone Institutes (US) | 2016-06-01 | — | — | EP | disclosed |
| US-9149463-B2 | Methods and compositions of treating a Flaviviridae family viral infection | THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY (US) | 2015-10-06 | — | — | US | disclosed |
| WO-2006016930-A2 | METHODS FOR TREATING HCV INFECTION | INTERMUNE, INC. (US) | 2006-02-16 | — | — | WO | disclosed |
| US-20050267018-A1 | Macrocyclic compounds as inhibitors of viral replication | HOFFMANN-LA ROCHE INC. | 2005-12-01 | — | — | US | disclosed |
| WO-2005110455-A2 | COMBINATION THERAPY FOR TREATING HEPATITIS VIRUS INFECTION | INTERMUNE, INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005067454-A2 | COMBINATION THERAPY FOR TREATING HEPATITIS C VIRUS INFECTION | VALEANT PHARMACEUTICALS NORTH AMERICA (US) | 2005-07-28 | — | — | WO | disclosed |
| WO-2005067963-A1 | USE OF POLYETHYLENE GLYCOL-MODIFIED INTERFERON-ALPHA IN THERAPEUTIC DOSING REGIMENS | INTERMUNE, INC. (US) | 2005-07-28 | — | — | WO | disclosed |
| WO-2005062949-A2 | METHOD FOR TREATING HEPATITIS VIRUS INFECTION | INTERMUNE, INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005037214-A2 | MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION | INTERMUNE, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
| EP-0788506-A2 | L-RIBOFURANOSYL NUCLEOSIDES | GENENCOR INTERNATIONAL, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| US-5559101-A | ANTITUMOR, ANTICARCINOGENIC, HIV | GENENCOR INTERNATIONAL, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| WO-1996013512-A2 | L-RIBOFURANOSYL NUCLEOSIDES | GENENCOR INTERNATIONAL, INC. (US) | 1996-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267018-A1 | Macrocyclic compounds as inhibitors of viral replication | EIF2AK2, HAVCR2, ZC3HAV1 | PYGM 286/4885LMNA 625/4885SMN1; SMN2 748/4885 |
| US-20180000926-A1 | METHODS OF INDUCING AN IMMUNE RESPONSE TO HEPATITIS C VIRUS | HAVCR2, CD74, IFNG | PYGM 1457/4885LMNA 4392/4885SMN1; SMN2 4252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.