Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455754 | 0.75 | HSD17B10 (0.54) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL30831943 | 0.73 | HSD17B10 (0.75) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL1097902 | 0.73 | HSD17B10 (0.75) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| Hydrochloric Acid SCHEMBL2527027 | 0.72 | HSD17B10 (0.73) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL24200136 | 0.71 | HSD17B10 (0.49) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL23229043 | 0.71 | HSD17B10 (0.62) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL23617368 | 0.70 | HSD17B10 (0.48) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL23229241 | 0.69 | HSD17B10 (0.59) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 | |
| SCHEMBL24200303 | 0.69 | AKR1C3 (0.44) | HSD17B10KDM4EAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL15935612 | 0.68 | HSD17B10 (0.70) | HSD17B10KDM4EAKR1C3PTGS1AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |