Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24200105 | 0.77 | CXCL8 (0.50) | MAPTL3MBTL1CAMK2A | |
| SCHEMBL8086435 | 0.77 | CXCL8 (0.50) | MAPTL3MBTL1CAMK2A | |
| SCHEMBL23656671 | 0.76 | ALDH1A1 (0.41) | KDM4EHSD17B10MAPTL3MBTL1TSHR | |
| SCHEMBL21437911 | 0.76 | POLB (0.51) | AKR1C3AKR1C2KDM4EHSD17B10MAPT | |
| SCHEMBL11070050 | 0.76 | HSD17B10 (0.50) | AKR1C3AKR1C2KDM4EHSD17B10MAPT | |
| SCHEMBL23229043 | 0.76 | HSD17B10 (0.62) | AKR1C3AKR1C2KDM4EHSD17B10MAPT | |
| SCHEMBL21455738 | 0.72 | TSHR (0.45) | AKR1C3AKR1C2KDM4EHSD17B10MAPT | |
| SCHEMBL23656620 | 0.71 | PDE10A (0.44) | KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL16930126 | 0.71 | THRB (0.51) | AKR1C3AKR1C2KDM4EHSD17B10MAPT | |
| SCHEMBL16267829 | 0.71 | KDM4E (0.52) | AKR1C3AKR1C2KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |