Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537757 | 0.96 | — | — | |
| Ammonia Solution, Strong SCHEMBL5269500 | 0.93 | — | — | |
| Ammonia Solution, Strong SCHEMBL15364012 | 0.93 | — | — | |
| SCHEMBL3359099 | 0.80 | ACHE (0.35) | ACHELDHALDHB | |
| SCHEMBL30671765 | 0.78 | ACHE (0.33) | ACHELDHALDHB | |
| Carbamic Acid SCHEMBL27956982 | 0.77 | ACHE (0.58) | ACHECA1CA2CA9LDHA | |
| SCHEMBL228466 | 0.76 | — | — | |
| Bicarbonate SCHEMBL2217045 | 0.76 | CA1 (0.50) | ACHECA1CA2CA9ALDH1A1 | |
| SCHEMBL10425379 | 0.72 | — | — | |
| Hydrazine SCHEMBL10591807 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022310-B1 | MICROORGANISMS AND METHODS FOR THE PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVED PRODUCTS | CARGILL INC (US) | 2019-10-16 | — | — | EP | disclosed |
| CN-103857660-A | For PET imaging18Direct synthesis of F-fluoromethoxy compounds and use thereof in direct radiosynthesis of O- ([ 2 ]18F]Novel precursors of protected derivatives of fluoromethyl) tyrosine | PIRAMAL IMAGING SA | 2014-06-11 | — | — | CN | disclosed |
| CN-103687866-A | Purine monophosphate prodrugs for the treatment of viral infections | RFS PHARMA LLC | 2014-03-26 | — | — | CN | disclosed |