SCHEMBL21456964

SCHEMBL21456964

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nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GABRR1 P24046 2/20 0.32
LMNA P02545 1/20 0.32
SLC22A6 Q4U2R8 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30
CPB1 P15086 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15485863 1.00 GABRR1 (0.32) GABRR1LMNASLC22A6TDP1SMN1; SMN2
SCHEMBL27150907 1.00 GABRR1 (0.32) GABRR1LMNASLC22A6TDP1SMN1; SMN2
Hydrochloric Acid SCHEMBL23780646 0.98 GABRR1 (0.31) GABRR1LMNASLC22A6TDP1
Hydrochloric Acid SCHEMBL23924127 0.98 GABRR1 (0.31) GABRR1LMNASLC22A6TDP1
SCHEMBL28501491 0.77
SCHEMBL15525400 0.74
SCHEMBL13482801 0.74
SCHEMBL13539959 0.74
SCHEMBL22256378 0.73 CYP2D6 (0.35)
SCHEMBL13786827 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790202-B Cyclic peptide, affinity chromatography carrier, labeled antibody, antibody drug complex and pharmaceutical preparation 富士胶片株式会社 2022-09-13 CN claimed
WO-2022104001-A1 EXPANDED PROTEIN LIBRARIES AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2022-05-19 WO claimed
US-20200237924-A1 CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS KINETA CHRONIC PAIN, LLC (US) 2020-07-30 US claimed
US-20250049943-A1 MEANS AND METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES ARARIS BIOTECH AG (CH) 2025-02-13 US disclosed
US-20240398972-A1 METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES ARARIS BIOTECH AG (CH) 2024-12-05 US disclosed
US-20240366782-A1 MEANS AND METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES ARARIS BIOTECH AG (CH) 2024-11-07 US disclosed
EP-4422695-A1 METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES Araris Biotech AG (CH) 2024-09-04 EP disclosed
US-12076412-B2 Antibody-drug conjugates through specific linker oligopeptides ARARIS BIOTECH AG (CH) 2024-09-03 US disclosed
WO-2024129990-A2 CHEMICALLY MODIFIED AAVS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2024-06-20 WO disclosed
CN-118159298-A Method for producing antibody-linker conjugates 阿拉里斯生物技术股份公司 2024-06-07 CN disclosed
CN-117750981-A Peptides comprising N-formyl-halomethionine residues and engineered antibody-peptide conjugates thereof 伊莱利利公司 2024-03-22 CN disclosed
WO-2022084560-A1 MEANS AND METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES ARARIS BIOTECH AG (CH) 2022-04-28 WO disclosed
WO-2022058594-A1 TRANSGLUTAMINASE CONJUGATION METHOD WITH AMINO ACID-BASED LINKERS ARARIS BIOTECH AG (CH) 2022-03-24 WO disclosed
EP-3941526-A1 TRANSGLUTAMINASE CONJUGATION METHOD WITH A GLYCINE BASED LINKER Paul Scherrer Institut (CH) 2022-01-26 EP disclosed
CN-113966339-A Conotoxin peptide analogs and uses for treating pain and inflammatory conditions 奇尼塔慢性疼痛有限责任公司 2022-01-21 CN disclosed
CN-113613679-A Transglutaminase conjugation methods for glycine-based linkers 保罗·谢勒学院 2021-11-05 CN disclosed
US-20200363423-A1 MISTRANSLATION METHOD FOR ASSESSING THE EFFECTS OF AMINO ACID SUBSTITUTIONS ON PROTEIN STABILITY AND FUNCTION UNIVERSITY OF WASHINGTON (US) 2020-11-19 US disclosed
WO-2020188061-A1 TRANSGLUTAMINASE CONJUGATION METHOD WITH A GLYCINE BASED LINKER PAUL SCHERRER INSTITUT (CH) 2020-09-24 WO disclosed
US-20200237924-A1 CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS KINETA CHRONIC PAIN, LLC (US) 2020-07-30 US disclosed
EP-3553078-A1 GLYCO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS Julius-Maximilians-Universität Würzburg (DE) 2019-10-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240398972-A1 METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES SP1, TGM1, KDM3A GABRR1 3719/4885LMNA 1731/4885SLC22A6 1669/4885
US-20200237924-A1 CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS CHRNG, CHRNA9, CHRNA10 GABRR1 180/4885LMNA 1324/4885SLC22A6 4517/4885
US-12076412-B2 Antibody-drug conjugates through specific linker oligopeptides TGM1, SP1, TGM3 GABRR1 2276/4885LMNA 2436/4885SLC22A6 2194/4885
US-20250049943-A1 MEANS AND METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES TGM1, TGM3, PRMT3 GABRR1 2382/4885LMNA 3084/4885SLC22A6 2870/4885
US-20240366782-A1 MEANS AND METHODS FOR PRODUCING ANTIBODY-LINKER CONJUGATES TGM1, TGM3, PRMT3 GABRR1 2382/4885LMNA 3084/4885SLC22A6 2870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.