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Sugi Predict / Targets / TGM1

TGM1

Protein-glutamine gamma-glutamyltransferase K · P22735 · TGM1 on Sugi Atlas →

15,576 patent compounds predicted against TGM1, 8,775 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1870113 SCHEMBL1870113 1.00 20/20
SCHEMBL1866323 SCHEMBL1866323 0.82 20/20
SCHEMBL1865911 SCHEMBL1865911 0.82 20/20
SCHEMBL1865047 SCHEMBL1865047 0.79 20/20
SCHEMBL1867457 SCHEMBL1867457 0.78 20/20
SCHEMBL1866256 SCHEMBL1866256 0.75 20/20
SCHEMBL1869953 SCHEMBL1869953 0.74 20/20
SCHEMBL1868994 SCHEMBL1868994 0.74 20/20
SCHEMBL1867975 SCHEMBL1867975 0.72 20/20
SCHEMBL1865035 SCHEMBL1865035 0.70 20/20
SCHEMBL1867609 SCHEMBL1867609 0.68 20/20
SCHEMBL1869787 SCHEMBL1869787 0.67 20/20
SCHEMBL1868569 SCHEMBL1868569 0.67 20/20
SCHEMBL1869147 SCHEMBL1869147 0.66 20/20
SCHEMBL1869605 SCHEMBL1869605 0.64 20/20
SCHEMBL1864416 SCHEMBL1864416 0.63 20/20
SCHEMBL1868015 SCHEMBL1868015 0.60 20/20
SCHEMBL1866126 SCHEMBL1866126 0.57 20/20
SCHEMBL1867063 SCHEMBL1867063 1.00 19/20
SCHEMBL1867574 SCHEMBL1867574 1.00 19/20

Clinical trials — most relevant to TGM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
SGM-101 in Locally Advanced and Recurrent Rectal Cancer PHASE2/PHASE3UNKNOWN
Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients PHASE3UNKNOWN
Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE) PHASE2/PHASE3RECRUITING
SGM-101 in Colorectal Brain Metastases. PHASE2UNKNOWN
SGM-101 in Colorectal Lung Metastases PHASE2UNKNOWN
A Phase II Open-label Single-arm Study to Evaluate the Efficacy and Safety of ADSCs in Subjects With Liver Cirrhosis PHASE2UNKNOWN
Triplezumab Combined With CAPEOX Regimen in Neoadjuvant Therapy for Locally Advanced Colon Cancer PHASE2UNKNOWN
Gadoxetate Enhanced Imaging Study to Detect Prostate Cancer PHASE2COMPLETED
An Efficacy and Safety Study of Mongersen (GED-0301) in Subjects With Active Ulcerative Colitis PHASE2COMPLETED
Alisertib in Treating Patients With Recurrent or Persistent Leiomyosarcoma of the Uterus PHASE2COMPLETED
Crizotinib in High-Risk Uveal Melanoma Following Definitive Therapy PHASE2COMPLETED
FORTRAS: A Study of MSK-TCR5 in People With Solid Tumor Cancers PHASE1RECRUITING
Single-Ascending Dose Study of JK07 in Subjects With HFpEF PHASE1WITHDRAWN
Phase 1 Clinical Study of GenSci155 Injection in Healthy Adults PHASE1NOT_YET_RECRUITING
A Randomized, Double-blind, Study to Explore the Effect of GED-0301 in Subjects With Active Crohn's Disease PHASE1COMPLETED
A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease PHASE1COMPLETED
A Phase I Trial to Investigate the Metabolism and Pharmacokinetics as Well as Safety and Tolerability of a Single Dose BI671800 HEA Administered as an Oral Solution of the Choline Salt in Healthy Male Volunteers PHASE1COMPLETED
A Study of GenSci098 in Subjects With Active Thyroid Eye Disease PHASE1RECRUITING
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma PHASE1COMPLETED
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers PHASE1COMPLETED
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart Failure nanUNKNOWN
a Single-arm, Single-center, Open Clinical Study nanRECRUITING
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol nanCOMPLETED
Calisthenics Versus High Intensity Interval Training in NAFL nanUNKNOWN
A Study to Assess the Genetic Variations in Bile Flow Disorders: Linking Progressive Familial Intrahepatic Cholestasis (PFIC)-Related Genes to Symptoms in Adults With Recurrent Cholestasis in Spain nanRECRUITING
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule nanUNKNOWN
'Glycogen Storage Diseases (GSDs) in Indian Children- Establishing an Indian GSD (I-GSD) Registry' nanRECRUITING
Observational Study of Actigraphy in Pediatric Pulmonary Arterial Hypertension nanCOMPLETED
Causes, Complications and Outcomes of Severe Acute Liver Disease Cases Admitted to Intensive Care Units nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TGM1 binder may also engage these)

ProteinNameSimilarity
P23606 — 1.000 P23606 →
P22758 — 1.000 P22758 →
Q9JLF6 — 1.000 Q9JLF6 →
Q9GLK0 — 1.000 Q9GLK0 →
O08619 — 0.995 O08619 →
F13A1 Coagulation factor XIII A chain 0.995 landscape →
P52181 — 0.994 P52181 →
A6QP57 — 0.994 A6QP57 →
Q05187 — 0.993 Q05187 →
Q9WVJ6 — 0.992 Q9WVJ6 →
P08587 — 0.992 P08587 →
Q8BH61 — 0.992 Q8BH61 →
P51176 — 0.991 P51176 →
Q08189 — 0.991 Q08189 →
P52183 — 0.990 P52183 →
P21981 — 0.990 P21981 →
Q01841 — 0.989 Q01841 →
D4A5U3 — 0.989 D4A5U3 →
TGM3 Protein-glutamine gamma-glutamyltransferase E 0.989 landscape →
Q8BZH1 — 0.988 Q8BZH1 →
TGM2 Protein-glutamine gamma-glutamyltransferase 0.987 landscape →
O88917 — 0.986 O88917 →
P53690 — 0.985 P53690 →
Q93WI9 — 0.985 Q93WI9 →
Q95220 — 0.984 Q95220 →
SMOX Spermine oxidase 0.984 landscape →
B4NBB0 — 0.984 B4NBB0 →
P49221 — 0.984 P49221 →
Q10739 — 0.984 Q10739 →
MMP14 Matrix metalloproteinase-14 0.984 landscape →