SCHEMBL21457740

SCHEMBL21457740

CCCOC(=O)/C(C#N)=C/c1ccc(F)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.57
ALDH1A1 P00352 11/20 0.56
KDM4E B2RXH2 2/20 0.56
DNM1 Q05193 3/20 0.56
L3MBTL1 Q9Y468 3/20 0.54
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
LMNA P02545 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
HTT P42858 2/20 0.51
PKM P14618 1/20 0.51
NPC1 O15118 1/20 0.51
MAPK1 P28482 1/20 0.51
CASP3 P42574 1/20 0.51
RAB9A P51151 1/20 0.51
SENP8 Q96LD8 1/20 0.51
SENP7 Q9BQF6 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21457743 1.00 MAPT (0.57) MAPTALDH1A1KDM4EDNM1L3MBTL1
SCHEMBL11071019 0.93 ALDH1A1 (0.63) MAPTALDH1A1KDM4EDNM1L3MBTL1
SCHEMBL11071030 0.93 ALDH1A1 (0.63) MAPTALDH1A1KDM4EDNM1L3MBTL1
SCHEMBL7466439 0.89 MAPT (0.71) MAPTALDH1A1KDM4EL3MBTL1MEN1
SCHEMBL12677352 0.89 MAPT (0.71) MAPTALDH1A1KDM4EL3MBTL1MEN1
SCHEMBL10361886 0.89 MAPT (0.71) MAPTALDH1A1KDM4EL3MBTL1MEN1
SCHEMBL21457255 0.87 DNM1 (0.60) MAPTALDH1A1KDM4EDNM1L3MBTL1
SCHEMBL21457173 0.87 ALDH1A1 (0.61) MAPTALDH1A1KDM4EDNM1L3MBTL1
SCHEMBL11417549 0.87 KDM4E (0.58) MAPTALDH1A1KDM4EDNM1
SCHEMBL21457177 0.87 ALDH1A1 (0.61) MAPTALDH1A1KDM4EDNM1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3553097-B1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORP (JP) 2022-05-04 EP disclosed
US-11225540-B2 Copolymer and optical film using same TOSOH CORPORATION (JP) 2022-01-18 US disclosed
US-20200095358-A1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORPORATION (JP) 2020-03-26 US disclosed
EP-3553097-A1 COPOLYMER AND OPTICAL FILM USING SAME Tosoh Corporation (JP) 2019-10-16 EP disclosed