Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145339 | 0.89 | NR1I2 (0.46) | KDM4EMEN1KMT2APKMMAPT | |
| SCHEMBL2145497 | 0.83 | RAB9A (0.49) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL2145157 | 0.83 | NR1I2 (0.39) | MEN1KMT2APKMNR1I2ITGB1 | |
| SCHEMBL2145641 | 0.82 | RAB9A (0.46) | KDM4EMEN1KMT2APKMMAPT | |
| SCHEMBL2145806 | 0.82 | CA12 (0.52) | KDM4EMEN1KMT2APKMMAPT | |
| SCHEMBL2145359 | 0.81 | MEN1 (0.44) | MEN1KMT2APKMNR1I2ITGB1 | |
| SCHEMBL2145513 | 0.81 | NR1I2 (0.58) | KDM4EMEN1KMT2AMAPTNR1I2 | |
| SCHEMBL2145236 | 0.80 | POLB (0.54) | KDM4EMEN1KMT2AMAPTNR1I2 | |
| SCHEMBL2145257 | 0.80 | NAMPT (0.42) | KDM4EMEN1KMT2ANR1I2POLB | |
| SCHEMBL2145580 | 0.79 | RAB9A (0.56) | KDM4EMEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |