Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145497 | 0.86 | RAB9A (0.49) | RAB9ANPC1TP53POLBFGFR1 | |
| SCHEMBL2145359 | 0.84 | MEN1 (0.44) | NR1I2TP53POLBITGB1ITGA4 | |
| SCHEMBL2145723 | 0.84 | NPC1 (0.52) | NR1I2RAB9ANPC1POLBMITF | |
| SCHEMBL2145641 | 0.83 | RAB9A (0.46) | NR1I2RAB9ANPC1TP53POLB | |
| SCHEMBL2145819 | 0.83 | KDM4E (0.41) | NR1I2RAB9ANPC1TP53POLB | |
| SCHEMBL2145339 | 0.82 | NR1I2 (0.46) | NR1I2RAB9ANPC1POLBITGB1 | |
| SCHEMBL2145716 | 0.81 | GHSR (0.42) | RAB9ANPC1FGFR1FGFR4SMN1; SMN2 | |
| SCHEMBL13651666 | 0.81 | KMT2A (0.46) | FGFR1FGFR4PKMALDH1A1TSHR | |
| SCHEMBL2145865 | 0.81 | MEN1 (0.43) | RAB9ANPC1POLBFGFR1FGFR4 | |
| SCHEMBL2145460 | 0.81 | SAE1 (0.55) | RAB9ANPC1FGFR1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |